CAS No. 2291360-73-9
Batch:
Purity:99.54
Chemical Structure
Check the
NVP-DKY709
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 3-[6-(1-benzylpiperidin-4-yl)-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione | |
|---|---|---|
| CAS Number | 2291360-73-9 | |
| Molecular Formula |
C25H27N3O3 |
|
| Molecular Weight (MW) | 417.50 | |
| SMILES | O=C1CCC(N2CC3=CC(=CC=C3C2=O)C4CCN(CC4)CC5=CC=CC=C5)C(=O)N1 | |
| InChIKey | OMISHRJQMYQPMG-UHFFFAOYSA-N |
NVP-DKY709 is a selective molecular glue degrader of zinc finger protein Helios (IKZF2) that recruits IKZF2 to the cereblon (CRBN) E3 ubiquitin ligase complex while sparing IKZF1 and IKZF3. By promoting targeted degradation of IKZF2, it impairs the suppressive activity of regulatory T (Treg) cells and restores cytokine production in exhausted effector T cells. In vivo, NVP-DKY709 delays tumor growth in humanized mouse models and enhances immunization responses. [1]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
10 mg/mL
(23.95 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.