CAS No. 1453082-52-4
Batch:
Purity:99.62
Chemical Structure
Check the
NVP-CLR457
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (4S,5R)-3-[6-[2-amino-4-(trifluoromethyl)pyrimidin-5-yl]-2-morpholin-4-ylpyrimidin-4-yl]-4-(hydroxymethyl)-5-methyl-1,3-oxazolidin-2-one | |
|---|---|---|
| CAS Number | 1453082-52-4 | |
| Molecular Formula |
C18H20F3N7O4 |
|
| Molecular Weight (MW) | 455.39 | |
| InChIKey | IEYOHYVYEJVEJJ-SKDRFNHKSA-N |
NVP-CLR457 is an orally bioavailable and potent pan-class I phosphoinositide 3-kinase (PI3K) inhibitor that targets the PI3Kα, PI3Kβ, PI3Kδ, and PI3Kγ isoforms. By disrupting class I PI3K enzymatic activity, NVP-CLR457 suppresses signaling through the downstream AKT/mTOR pathway. This pathway inhibition blocks signal transduction, resulting in decreased cell survival, impaired proliferation, and dose-dependent antitumor activity in preclinical tumor xenograft models. [1]
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Concentration
Volume
Mass
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|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
91 mg/mL
(199.82 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 3 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.