CAS No. 675576-97-3
Batch:
Purity:99.88
Chemical Structure
Check the
Nutlin-3b
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 675576-97-3 | |
|---|---|---|
| Molecular Formula |
C30H30Cl2N4O4 |
|
| Molecular Weight (MW) | 581.49 | |
| SMILES | CC(C)OC1=C(C=CC(=C1)OC)C2=NC(C(N2C(=O)N3CCNC(=O)C3)C4=CC=C(C=C4)Cl)C5=CC=C(C=C5)Cl |
Nutlin-3b is an MDM2 antagonist that inhibits the MDM2-p53 interaction (IC50 13.6 μM), serving as the 150-fold less potent (+)-enantiomer of Nutlin-3 compared to Nutlin-3a. Disruption of MDM2-p53 binding normally restores p53 pathway activity; however, due to its low binding affinity, Nutlin-3b fails to efficiently induce p53-dependent transcriptional activation, G1/S cell cycle arrest, or apoptosis in target cells. [1]
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Concentration
Volume
Mass
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|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(171.97 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 100 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
Note: Technical data last updated: Sep 1, 2026.