CAS No. 161058-83-9
Batch:
Purity:99.32
Chemical Structure
Check the
NU2058
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 6-(cyclohexylmethoxy)-7H-purin-2-amine | |
|---|---|---|
| CAS Number | 161058-83-9 | |
| Molecular Formula |
C12H17N5O |
|
| Molecular Weight (MW) | 247.30 | |
| SMILES | C1CCC(CC1)COC2=NC(=NC3=C2NC=N3)N | |
| InChIKey | MWGXGTJJAOZBNW-UHFFFAOYSA-N |
Biological Activity
NU2058 is a guanine-based cyclin-dependent kinase inhibitor targeting CDK2 (IC50 =. By inhibiting CDK2 kinase activity, NU2058 impairs cell cycle progression and disrupts downstream cell cycle pathways. It selectively potentiates the cytotoxic activity of alkylating agents such as melphalan and monohydroxymelphalan in cancer cells, while showing no enhancement with temozolomide or ionizing radiation. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
49 mg/mL
(198.13 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 49 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.