CAS No. 2771019-10-2
Batch:
Purity:99.4
Chemical Structure
Check the
NT-0527
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 2-(6-chloro-1-oxospiro[3H-isoquinoline-4,1'-cyclopropane]-2-yl)-N-(5-fluoropyrimidin-2-yl)acetamide | |
|---|---|---|
| CAS Number | 2771019-10-2 | |
| Molecular Formula |
C17H14ClFN4O2 |
|
| Molecular Weight (MW) | 360.77 | |
| InChIKey | IJKUKVUCVMOGHG-UHFFFAOYSA-N |
NT-0527 is a potent, brain-penetrant inhibitor of the NLRP3 inflammasome. By selectively targeting NLRP3, it inhibits inflammasome assembly and downstream activation of inflammatory cascades. This inhibition blocks the release of pro-inflammatory cytokines such as IL-1β and IL-18, mitigating neuroinflammation and systemic inflammatory responses in animal models. NT-0527 exhibits oral bioavailability and demonstrates potent anti-inflammatory efficacy in vivo.
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
24 mg/mL
(66.52 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.