CAS No. 138736-73-9
Batch:
Purity:99.94
Chemical Structure
Check the
HAMNO
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 1-[(2-hydroxyphenyl)iminomethyl]naphthalen-2-ol | |
|---|---|---|
| CAS Number | 138736-73-9 | |
| Molecular Formula |
C17H13NO2 |
|
| Molecular Weight (MW) | 263.29 | |
| SMILES | C1=CC=C2C(=C1)C=CC(=C2C=NC3=CC=CC=C3O)O | |
| InChIKey | FMIVOPRNBGRDKP-UHFFFAOYSA-N |
HAMNO is a selective replication protein A (RPA) inhibitor that displays anti-tumor activity. By interfering with RPA function, HAMNO blocks both ATR autophosphorylation and ATR-mediated phosphorylation of RPA32 at Ser33. Disruption of this ATR-RPA signaling cascade impairs the cellular DNA damage response and inhibits DNA replication in cancer cells, ultimately suppressing tumor cell proliferation.
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
53 mg/mL
(201.29 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.