CAS No. 56990-57-9
Chemical Structure
Check the
NSC-87877
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| CAS Number | 56990-57-9 | |
|---|---|---|
| Molecular Formula |
C19H13N3O7S2 |
|
| Molecular Weight (MW) | 459.46 |
Biological Activity
NSC-87877 is a potent inhibitor of protein tyrosine phosphatase Shp2 (IC50 of 0.318 μM) and Shp1 (IC50 of 0.355 μM) that also inhibits dual-specificity phosphatase 26 (DUSP26). By blocking Shp2 phosphatase activity, it modulates receptor tyrosine kinase signaling and attenuates epidermal growth factor-stimulated ERK1/2 activation within the Ras/MAPK pathway. Consequently, NSC-87877 suppresses growth factor-induced cellular responses and inhibits oncogenic signaling phenotypes.
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Note: Technical data last updated: Sep 1, 2026.