CAS No. 58131-57-0
Batch:
Purity:99.05
Chemical Structure
Check the
NSC 207895
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 4-(4-methylpiperazin-1-yl)-7-nitro-3-oxido-2,1,3-benzoxadiazol-3-ium | |
|---|---|---|
| CAS Number | 58131-57-0 | |
| Molecular Formula |
C11H13N5O4 |
|
| Molecular Weight (MW) | 279.25 | |
| SMILES | CN1CCN(CC1)C2=CC=C(C3=NO[N+](=C23)[O-])[N+](=O)[O-] | |
| InChIKey | MWFZDJLPWDCQIL-UHFFFAOYSA-N |
NSC 207895 (XI-006) is a nitrobenzofuroxan derivative and small-molecule inhibitor targeting MDMX and regulating MDM2. By suppressing MDMX transcription and activity, it attenuates MDMX-mediated inhibition of p53, leading to p53 pathway reactivation. This upregulation of p53 drives increased transcriptional expression of pro-apoptotic target genes, including BAX and PUMA, ultimately inducing apoptosis and suppressing cancer cell viability. [1]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| 5%TFA | 6 mg/mL |
| DMSO |
0.4 mg/mL
(1.43 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Water | Insoluble |
| DMSO |
36 mg/mL
(128.91 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
Note: Technical data last updated: Sep 1, 2026.