CAS No. 1099592-35-4
Batch:
Purity:98.97
Chemical Structure
Check the
NSAH
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| CAS Number | 1099592-35-4 | |
|---|---|---|
| Molecular Formula |
C18H14N2O3 |
|
| Molecular Weight (MW) | 306.32 | |
| SMILES | OC1=CC=CC=C1C(=O)N\N=C\C2=C3C=CC=CC3=CC=C2O |
Biological Activity
NSAH is a reversible and competitive nonnucleoside ribonucleotide reductase (RNR) inhibitor. By selectively targeting RNR, the compound impairs the enzymatic conversion of ribonucleotides into deoxyribonucleotides, depleting dNTP pools necessary for genomic replication. Consequently, NSAH suppresses DNA synthesis and downstream cell cycle progression, leading to the inhibition of cellular proliferation in preclinical cancer cell models. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
61 mg/mL
(199.13 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
Jump to
Note: Technical data last updated: Sep 1, 2026.