CAS No. 353262-04-1
Batch:
Purity:99.97
Chemical Structure
Check the
NS6180
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 4-[[3-(trifluoromethyl)phenyl]methyl]-1,4-benzothiazin-3-one | |
|---|---|---|
| CAS Number | 353262-04-1 | |
| Molecular Formula |
C16H12F3NOS |
|
| Molecular Weight (MW) | 323.33 | |
| SMILES | C1C(=O)N(C2=CC=CC=C2S1)CC3=CC(=CC=C3)C(F)(F)F | |
| InChIKey | ZUIJXKLTUFCDGO-UHFFFAOYSA-N |
NS6180 is a highly potent and selective small-molecule inhibitor of the intermediate-conductance calcium-activated potassium channel KCa3.1 (IC50 = 9 nM). Pharmacological blockade of KCa3.1 by NS6180 suppresses membrane hyperpolarization and intracellular calcium influx. This inhibition impairs downstream signaling cascades required for T cell activation, lymphocyte proliferation, and pro-inflammatory cytokine secretion, ultimately attenuating tissue inflammation and immune-mediated inflammatory responses.
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
65 mg/mL
(201.03 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 33 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.