CAS No. 343630-41-1
Batch:
Purity:99.82
Chemical Structure
Check the
NS3623
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 343630-41-1 | |
|---|---|---|
| Molecular Formula |
C15H10BrF3N6O |
|
| Molecular Weight (MW) | 427.18 |
NS3623 is a small-molecule activator of human ether-a-go-go-related gene (hERG1/Kv potassium channels that exhibits a dual mode of action by both activating and inhibiting hERG1 channels. Activation of hERG1 enhances rapid delayed rectifier (IKr) and transient outward (Ito) potassium currents, driving cellular repolarization. Downstream, NS3623 shortens cardiac action potential duration, improves repolarization reserve, and displays antiarrhythmic phenotypic effects. [1][2]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
85 mg/mL
(198.97 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 21 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.