CAS No. 1566-81-0
Batch:
Purity:99.94
Chemical Structure
Check the
NS1652
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 2-[[3-(trifluoromethyl)phenyl]carbamoylamino]benzoic acid | |
|---|---|---|
| CAS Number | 1566-81-0 | |
| Molecular Formula |
C15H11F3N2O3 |
|
| Molecular Weight (MW) | 324.25 | |
| SMILES | OC(=O)C1=CC=CC=C1NC(=O)NC2=CC=CC(=C2)C(F)(F)F | |
| InChIKey | CTNQAPPDQTYTHM-UHFFFAOYSA-N |
Biological Activity
NS1652 is a reversible chloride channel blocker that potently inhibits chloride conductance in human and mouse red blood cells, while displaying weak activity against volume-activated anion conductance (VRAC) in HEK293 cells. By impairing transmembrane anion flux, NS1652 modulates red blood cell membrane conductance and cellular volume regulation, thereby suppressing swelling-induced ion transport downstream of osmotic stress pathways.
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
65 mg/mL
(200.46 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 65 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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Note: Technical data last updated: Sep 1, 2026.