CAS No. 1221713-92-3
Batch:
Purity:99.72
Chemical Structure
Check the
NPS-1034
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 1-(4-fluorophenyl)-N-[3-fluoro-4-[(3-phenyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy]phenyl]-2,3-dimethyl-5-oxopyrazole-4-carboxamide | |
|---|---|---|
| CAS Number | 1221713-92-3 | |
| Molecular Formula |
C31H23F2N5O3 |
|
| Molecular Weight (MW) | 551.54 | |
| SMILES | CC1=C(C(=O)N(N1C)C2=CC=C(C=C2)F)C(=O)NC3=CC(=C(C=C3)OC4=C5C(=CNC5=NC=C4)C6=CC=CC=C6)F | |
| InChIKey | RGAZVGZUBCFHRJ-UHFFFAOYSA-N |
Biological Activity
NPS-1034 is a potent dual inhibitor of c-Met (IC50 of 48 nM) and Axl (IC50 of 10.3 nM). By targeting these receptor tyrosine kinases, the compound blocks downstream phosphorylation within the AKT and ERK signaling pathways. Consequently, NPS-1034 suppresses cell proliferation and triggers apoptosis in cancer cell lines, effectively overcoming resistance to EGFR inhibitors in non-small cell lung cancer models. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(181.31 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 4 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer longer shelf life compared to stock solutions.
Looking for a specific aliquot size? Contact your local sales representative or orders@selleckchem.com.
Reference
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Note: Technical data last updated: Sep 1, 2026.