CAS No. 41332-24-5
Batch:
Purity:99.55
Chemical Structure
Check the
NP118809
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 1-(4-benzhydrylpiperazin-1-yl)-3,3-diphenylpropan-1-one | |
|---|---|---|
| CAS Number | 41332-24-5 | |
| Molecular Formula |
C32H32N2O |
|
| Molecular Weight (MW) | 460.61 | |
| SMILES | C1CN(CCN1C(C2=CC=CC=C2)C3=CC=CC=C3)C(=O)CC(C4=CC=CC=C4)C5=CC=CC=C5 | |
| InChIKey | VCPMZDWBEWTGNW-UHFFFAOYSA-N |
NP118809 is a small-molecule calcium channel blocker that acts on N-type voltage-gated calcium channels (Cav2.2) and L-type calcium channels. Blockade of presynaptic N-type calcium channels prevents activity-dependent calcium influx into nociceptive nerve terminals, suppressing excitatory neurotransmitter release in spinal dorsal horn pathways. Consequently, this dampens pain signal transmission and modulates downstream neuronal excitability involved in nociceptive processing. [1][2]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
92 mg/mL
(199.73 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 3 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.