CAS No. 898211-21-7

Batch: Purity:97.76
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NOX-6-18（GPR132-B-160） Chemical Structure
Chemical Structure
Check the NOX-6-18（GPR132-B-160） product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 3-methyl-5-(2-phenylethylsulfamoyl)-1-benzofuran-2-carboxylic acid
CAS Number 898211-21-7
Molecular Formula

C18H17NO5S
Molecular Weight (MW) 359.40
InChIKey XFMCZHXUAWBOAL-UHFFFAOYSA-N

Biological Activity

NOX-6-18 (GPR132-B-160) functions as a potent and selective antagonist of G protein-coupled receptor 132 (GPR132). Targeted blockade of GPR132-mediated signaling regulates macrophage reprogramming within pancreatic islets, which suppresses local inflammatory responses and promotes overall metabolic homeostasis, ultimately resulting in significantly reduced weight gain and improved glucose metabolism in mice maintained on a high-fat diet.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 72 mg/mL (200.33 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.