CAS No. 894-71-3

Batch: Purity:99.97
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Nortriptyline hydrochloride Chemical Structure
Chemical Structure
Check the Nortriptyline hydrochloride product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name N-methyl-3-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaenylidene)propan-1-amine;hydrochloride
CAS Number 894-71-3
Molecular Formula

C19H21N.HCl
Molecular Weight (MW) 299.84
SMILES CNCCC=C1C2=CC=CC=C2CCC3=CC=CC=C31.Cl
InChIKey SHAYBENGXDALFF-UHFFFAOYSA-N

Biological Activity

Nortriptyline hydrochloride is a tricyclic antidepressant that functions primarily as a selective norepinephrine reuptake inhibitor and serotonin reuptake inhibitor. By inhibiting the norepinephrine transporter (NET) and serotonin transporter (SERT), it prevents monoamine reuptake into presynaptic terminals. This blockade enhances synaptic norepinephrine and serotonin signaling in the central nervous system, modulating downstream neurochemical pathways and neurobehavioral phenotypes. [1]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 59 mg/mL (196.77 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 59 mg/mL
Ethanol 59 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Tatsumi M, et al. Eur J Pharmacol. 1997;340(2-3):249-58.

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Note: Technical data last updated: Sep 1, 2026.