CAS No. 329-56-6

Batch: Purity:99.81
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Norepinephrine hydrochloride Chemical Structure
Chemical Structure
Check the Norepinephrine hydrochloride product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 4-[(1R)-2-amino-1-hydroxyethyl]benzene-1,2-diol;hydrochloride
CAS Number 329-56-6
Molecular Formula

C8H11NO3.ClH
Molecular Weight (MW) 205.64
InChIKey FQTFHMSZCSUVEU-QRPNPIFTSA-N

Ordering Information

Biological Activity

Norepinephrine hydrochloride is a potent adrenergic receptor agonist that activates α1, α2, and β1 adrenoceptors. Upon binding to these G protein-coupled receptors, norepinephrine triggers downstream intracellular signaling cascades, including adenylyl cyclase and phospholipase C pathways. These receptor-mediated responses play a central role in modulating sympathetic nervous system activity, regulating vascular smooth muscle contraction, and controlling systemic blood pressure and cardiac function.[1][2]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 41 mg/mL (199.37 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 41 mg/mL
Ethanol 14 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.