CAS No. 4674-50-4
Batch:
Purity:97
Chemical Structure
Check the
Nootkatone
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 4674-50-4 | |
|---|---|---|
| Molecular Formula |
C15H22O |
|
| Molecular Weight (MW) | 218.33 |
Nootkatone is a natural sesquiterpenoid component that acts as an activator of AMP-activated protein kinase (AMPK). Activation of AMPK by nootkatone enhances energy metabolism, stimulates fatty acid oxidation, and suppresses lipid accumulation in metabolic tissues. Furthermore, nootkatone exhibits pronounced antioxidant and anti-inflammatory activities by suppressing NF-kB signaling and oxidative stress, thereby protecting against diet-induced obesity and inflammatory injury. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
44 mg/mL
(201.52 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 44 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.