CAS No. 58652-20-3
Batch:
Purity:99.96
Chemical Structure
Check the
Nomegestrol Acetate
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 58652-20-3 | |
|---|---|---|
| Molecular Formula |
C23H30O4 |
|
| Molecular Weight (MW) | 370.48 | |
| SMILES | CC(=O)OC1(CCC2C3C=C(C)C4=CC(=O)CCC4C3CCC12C)C(C)=O |
Nomegestrol acetate is a highly selective steroidal progestogen that functions as a full agonist at the progesterone receptor (PR), displaying minimal binding affinity for androgen, glucocorticoid, or estrogen receptors. Selective activation of PR signaling suppresses hypothalamic-pituitary gonadotropin secretion, leading downstream to the inhibition of ovulation and suppression of estrogen-driven proliferation in hormone-sensitive tissues. [1][2]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
74 mg/mL
(199.74 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 18 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.