CAS No. 42464-96-0

Batch: Purity:99.77
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NNMTi Chemical Structure
Chemical Structure
Check the NNMTi product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 1-methylquinolin-1-ium-5-amine iodide
CAS Number 42464-96-0
Molecular Formula

C10H11N2.I
Molecular Weight (MW) 286.11
SMILES [I-].C[N+]1=CC=CC2=C(N)C=CC=C12
InChIKey JPEZFBFIRRAFNR-UHFFFAOYSA-N

Ordering Information

Biological Activity

NNMTi (Compound 1k) is a small-molecule nicotinamide N-methyltransferase (NNMT) inhibitor with an ICof. By blocking NNMT activity, the compound regulates cellular methyl donor levels and nicotinamide adenine dinucleotide (NAD+) metabolic pathways. Downstream, NNMT inhibition activates senescent muscle stem cells, promoting myoblast differentiation and enhancing the overall regenerative capacity of skeletal muscle tissue. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 57 mg/mL (199.22 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 5 mg/mL
Ethanol 3 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.