CAS No. 1262417-51-5
Batch:
Purity:99.90
Chemical Structure
Check the
NMS-P118
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 2-[1-(4,4-difluorocyclohexyl)piperidin-4-yl]-6-fluoro-3-oxo-1H-isoindole-4-carboxamide | |
|---|---|---|
| CAS Number | 1262417-51-5 | |
| Molecular Formula |
C20H24F3N3O2 |
|
| Molecular Weight (MW) | 395.42 | |
| SMILES | C1CC(CCC1N2CCC(CC2)N3CC4=C(C3=O)C(=CC(=C4)F)C(=O)N)(F)F | |
| InChIKey | ARYVAQSYRLZVQD-UHFFFAOYSA-N |
NMS-P118 is an orally bioavailable and highly selective poly(ADP-ribose) polymerase 1 (PARP-1) inhibitor. By targeting PARP-1, it impairs single-strand DNA break repair mechanisms and leads to the accumulation of double-strand DNA breaks. This inhibition disrupts DNA damage response pathways, ultimately driving synthetic lethality and cell apoptosis in homologous recombination-deficient cancer cells. [1]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
79 mg/mL
(199.78 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 10 mg/mL |
| Water | Insoluble |
| DMSO |
24 mg/mL
(60.69 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 5 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.