CAS No. 2922281-15-8
Batch:
Purity:99.62
Chemical Structure
Check the
Coronastat(NK01-63)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | sodium (2S)-1-hydroxy-2-[[(2S)-4-methyl-2-[[3-(trifluoromethyl)phenyl]methoxycarbonylamino]pentanoyl]amino]-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonate | |
|---|---|---|
| CAS Number | 2922281-15-8 | |
| Molecular Formula |
C22H29F3N3NaO8S |
|
| Molecular Weight (MW) | 575.53 | |
| SMILES | CC(C)CC(NC(=O)OCC1=CC(=CC=C1)C(F)(F)F)C(=O)NC(CC2CCNC2=O)C(O)[S](=O)(=O)O[Na] | |
| InChIKey | KOKDRBNCVDMTCL-OPOLGWMESA-M |
Biological Activity
Coronastat (NK01- is a small-molecule peptidomimetic inhibitor targeting the SARS-CoV-2 3CL protease (main protease). By directly inhibiting the enzymatic catalytic activity of the 3CL protease, Coronastat blocks essential viral polyprotein processing and cleavage maturation required for assembly. Consequently, disruption of this critical viral maturation pathway prevents effective viral replication and impairs overall cellular coronavirus infection. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(173.75 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 100 mg/mL |
| Ethanol | 100 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.