CAS No. 4008-48-4

Batch: Purity:99.91
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Nitroxoline Chemical Structure
Chemical Structure
Check the Nitroxoline product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 5-nitroquinolin-8-ol
CAS Number 4008-48-4
Molecular Formula

C9H6N2O3
Molecular Weight (MW) 190.16
SMILES C1=CC2=C(C=CC(=C2N=C1)O)[N+](=O)[O-]
InChIKey RJIWZDNTCBHXAL-UHFFFAOYSA-N

Ordering Information

Biological Activity

Nitroxoline is a urinary antibacterial agent and selective inhibitor of cathepsin B activity. By blocking cathepsin B, it suppresses extracellular matrix degradation, tumor cell invasion, and overall tumor progression both in vitro and in vivo. Additionally, nitroxoline inhibits endothelial cell proliferation and tumor angiogenesis, leading to significant suppression of tumor growth in preclinical models. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 38 mg/mL (199.83 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.