CAS No. 98636-73-8

Batch: Purity:98.14
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Nitrocaramiphen hydrochloride Chemical Structure
Chemical Structure
Check the Nitrocaramiphen hydrochloride product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 98636-73-8
Molecular Formula

C18H26N2O4.ClH
Molecular Weight (MW) 370.87
SMILES Cl.CCN(CC)CCOC(=O)C1(CCCC1)C2=CC=C(C=C2)[N+]([O-])=O

Biological Activity

Nitrocaramiphen hydrochloride is a competitive antagonist of muscarinic acetylcholine receptor M1 (mAChR M1, Ki 5.5 nM), exhibiting 71-fold selectivity over mAChR M2 and 10-fold selectivity over mAChR M3. By selectively blocking cholinergic signaling through mAChR M1, it inhibits agonist-mediated receptor activation and completely removes muscarine-induced cellular hyperpolarizing responses in target tissues. [1]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
Ethanol 18 mg/mL
DMSO 9 mg/mL (24.26 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 3 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Hudkins RL, et al. Eur J Pharmacol. 1993;231(3):485-488.

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Note: Technical data last updated: Sep 1, 2026.