CAS No. 656247-18-6
Batch:
Purity:99.99
Chemical Structure
Check the
Nintedanib Ethanesulfonate Salt
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | ethanesulfonic acid;methyl 2-hydroxy-3-[N-[4-[methyl-[2-(4-methylpiperazin-1-yl)acetyl]amino]phenyl]-C-phenylcarbonimidoyl]-1H-indole-6-carboxylate | |
|---|---|---|
| CAS Number | 656247-18-6 | |
| Molecular Formula |
C31H33N5O4.C2H6O3S |
|
| Molecular Weight (MW) | 649.76 | |
| SMILES | CCS(=O)(=O)O.CN1CCN(CC1)CC(=O)N(C)C2=CC=C(C=C2)N=C(C3=CC=CC=C3)C4=C(NC5=C4C=CC(=C5)C(=O)OC)O | |
| InChIKey | ZNMRDZZRAFJOKY-UHFFFAOYSA-N |
Nintedanib Ethanesulfonate Salt is a small molecule tyrosine-kinase inhibitor targeting VEGFR1, VEGFR2, VEGFR3, FGFR1, FGFR2, FGFR3, PDGFRα, and PDGFRβ. By blocking receptor autophosphorylation and downstream receptor tyrosine kinase signaling, it suppresses cell proliferation and migration, leading to inhibition of tumor angiogenesis and fibrotic processes. [1]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(153.9 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 10 mg/mL (超声加热10min) |
| Ethanol | Insoluble |
| DMSO |
100 mg/mL
(153.9 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 12.5 mg/mL |
| Ethanol | 5 mg/mL |
| DMSO |
100 mg/mL
(153.9 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 100 mg/mL |
| Ethanol | Insoluble |
| DMSO |
100 mg/mL
(153.9 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 25 mg/mL |
| Ethanol | 13 mg/mL |
| DMSO |
100 mg/mL
(153.9 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 20 mg/mL |
| Ethanol | 3 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
- Nintedanib Ethanesulfonate Salt Clinical Trials
- Nintedanib Ethanesulfonate Salt Solubility in DMSO
- Nintedanib Ethanesulfonate Salt Stock Solution
- Nintedanib Ethanesulfonate Salt Storage
- Nintedanib Ethanesulfonate Salt Stability
- Nintedanib Ethanesulfonate Salt Molecular Weight
- Nintedanib Ethanesulfonate Salt SMILES
- Nintedanib Ethanesulfonate Salt Chemical Structure (2D and 3D)
- Nintedanib Ethanesulfonate Salt SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.