CAS No. 2311824-72-1

Batch: Purity:98.72
Check CoA
Ninerafaxstat trihydrochloride Chemical Structure
Chemical Structure
Check the Ninerafaxstat trihydrochloride product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 2-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl]ethyl pyridine-3-carboxylate;trihydrochloride
CAS Number 2311824-72-1
Molecular Formula

C22H29N3O5.3ClH
Molecular Weight (MW) 524.87
InChIKey XDBODYSZDLGFRQ-UHFFFAOYSA-N

Ordering Information

Biological Activity

Ninerafaxstat trihydrochloride is an orally active competitive inhibitor of-ketoacyl-CoA thiolase -KAT). By partially suppressing mitochondrial fatty acid oxidation, it shifts myocardial substrate utilization from fatty acids toward glucose oxidation. This metabolic modulation increases overall cardiac energy efficiency, optimizes cellular adenosine triphosphate production, and helps restore myocardial energy homeostasis under ischemic or metabolic stress conditions. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
🧮 Molarity Calculator

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
Water 90 mg/mL
DMSO 45 mg/mL (85.73 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Jump to

Note: Technical data last updated: Sep 1, 2026.