CAS No. 1660114-31-7
Batch:
Purity:99.85
Chemical Structure
Check the
NIK SMI1
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 6-[3-[2-[(3R)-3-hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]phenyl]-4-methoxypyridine-2-carboxamide | |
|---|---|---|
| CAS Number | 1660114-31-7 | |
| Molecular Formula |
C20H19N3O4
|
|
| Molecular Weight (MW) | 365.38 | |
| SMILES | CN1CCC(C1=O)(C#CC2=CC(=CC=C2)C3=NC(=CC(=C3)OC)C(=O)N)O | |
| InChIKey | LQSHXYHWYGKAMX-FQEVSTJZSA-N |
NIK SMI1 is a potent and selective inhibitor of NF-κB-inducing kinase (NIK) that targets the non-canonical NF-κB signaling pathway. By suppressing NIK catalytic activity, it prevents the downstream phosphorylation and proteolytic processing of p100 to p52, thereby dampening NF-κB-dependent gene transcription. Consequently, inhibition of this pathway suppresses inflammatory responses and impairs cell proliferation and survival in various disease models. [1][2]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
73 mg/mL
(199.79 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.