CAS No. 1341-23-7

Batch: Purity:99.73
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Nicotinamide riboside Chemical Structure
Chemical Structure
Check the Nicotinamide riboside product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyridin-1-ium-3-carboxamide
CAS Number 1341-23-7
Molecular Formula

C11H15N2O5
Molecular Weight (MW) 255.25
InChIKey JLEBZPBDRKPWTD-TURQNECASA-O

Biological Activity

Nicotinamide riboside is an orally active precursor of nicotinamide adenine dinucleotide (NAD+) that supports cellular energy metabolism and mitochondrial function. Supplementation with nicotinamide riboside increases intracellular NAD+ pools, thereby activating NAD+-dependent sirtuins including SIRT1 and SIRT3. This pathway activation enhances oxidative metabolism, improves metabolic homeostasis, and protects against high-fat diet-induced metabolic disorders in vivo. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 51 mg/mL (199.8 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 51 mg/mL
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Cantó C, et al. Cell Metab. 2012;15(6):838-47.

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Note: Technical data last updated: Sep 1, 2026.