CAS No. 27848-84-6

Batch: Purity:99.74
Check CoA
Nicergoline Chemical Structure
Chemical Structure
Check the Nicergoline product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 27848-84-6
Molecular Formula

C24H26BrN3O3
Molecular Weight (MW) 484.39
SMILES CN1CC(CC2(C1CC3=CN(C4=CC=CC2=C34)C)OC)COC(=O)C5=CC(=CN=C5)Br

Ordering Information

Biological Activity

Nicergoline is an ergot derivative that acts as a selective alpha-1A adrenergic receptor antagonist. By blocking alpha-1 adrenergic receptor signaling, it inhibits receptor-mediated phosphoinositide hydrolysis and intracellular calcium mobilization. Downstream, this antagonism modulates neuronal neurotransmitter release, promotes cholinergic pathway activity, and exerts neuroprotective effects against oxidative stress and ischemic cell damage.

How to Prepare Stock Solution?

Concentration Volume Mass
🧮 Molarity Calculator

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 22 mg/mL (45.41 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Jump to

Note: Technical data last updated: Sep 1, 2026.