CAS No. 2115742-03-3
Batch:
Purity:99.75
Chemical Structure
Check the
NHWD-870
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 5-(3,5-dimethyltriazol-4-yl)-12-methyl-8-[(S)-oxan-4-yl(phenyl)methyl]-3,8,12,13-tetrazatetracyclo[7.7.0.02,7.011,15]hexadeca-1(9),2(7),3,5,10,13,15-heptaene | |
|---|---|---|
| CAS Number | 2115742-03-3 | |
| Molecular Formula |
C29H29N7O |
|
| Molecular Weight (MW) | 491.59 | |
| InChIKey | YMSCCGUMGIFOSI-GDLZYMKVSA-N |
NHWD-870 is a potent bromodomain and extra-terminal (BET) family inhibitor that selectively targets BRD2, BRD, BRD4, and BRDT. Mechanistically, NHWD-870 suppresses BRD4 activity and its downstream target HIF1α, resulting in the inhibition of CSF1 expression. This transcriptional suppression disrupts tumor cell–macrophage crosstalk, blocking tumor-associated macrophage proliferation and attenuating tumor cell growth in solid tumors. [1]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
12 mg/mL
(24.41 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
14 mg/mL
(28.47 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.