CAS No. 101187-40-0

Batch: Purity:
NH2-PEG3-C2-NH-Boc Chemical Structure
Chemical Structure
Check the NH2-PEG3-C2-NH-Boc product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 101187-40-0
Molecular Formula

C13H28N2O5
Molecular Weight (MW) 292.37
SMILES CC(C)(C)OC(=O)NCCOCCOCCOCCN

Biological Activity

NH2-PEG3-C2-NH-Boc is a polyethylene glycol (PEG)-based PROTAC linker utilized in the synthesis of proteolysis targeting chimeras (PROTACs). By providing optimal spatial flexibility and solubility, PEG-based linkers facilitate the efficient assembly of a target protein-PROTAC-E3 ligase ternary complex. This structural orientation recruits E3 ubiquitin ligases to induce selective ubiquitination and subsequent proteasomal degradation of target proteins across various cellular pathways. [1]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Sun X, et al. Signal Transduct Target Ther. 2019;4:64.

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Note: Technical data last updated: Sep 1, 2026.