CAS No. 212779-48-1
Batch:
Purity:99.98
Chemical Structure
Check the
NG 52
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 2-[[6-(3-chloroanilino)-9-propan-2-ylpurin-2-yl]amino]ethanol | |
|---|---|---|
| CAS Number | 212779-48-1 | |
| Molecular Formula |
C16H19ClN6O |
|
| Molecular Weight (MW) | 346.81 | |
| SMILES | CC(C)N1C=NC2=C(N=C(N=C21)NCCO)NC3=CC(=CC=C3)Cl | |
| InChIKey | XZEFMZCNXDQXOZ-UHFFFAOYSA-N |
NG 52 is a tri-substituted purine derivative that acts as an ATP-competitive kinase inhibitor targeting yeast cyclin-dependent kinases, including Pho85p and Cdc28p. By binding to the ATP-binding catalytic cleft of cyclin-dependent kinases, this compound modulates kinase-dependent phosphorylation cascades. Consequently, inhibition of these central cell cycle regulators impacts downstream cell cycle progression, transcriptional regulation, and cellular metabolic pathways. [1]
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Concentration
Volume
Mass
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|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
69 mg/mL
(198.95 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 23 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.