CAS No. 1227098-15-8

Batch: Purity:99.44
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NF-κB-IN-1 Chemical Structure
Chemical Structure
Check the NF-κB-IN-1 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (1E,6E)-1,7-bis(3,4-dimethoxyphenyl)-4-[(4-hydroxy-3-methoxyphenyl)methylidene]hepta-1,6-diene-3,5-dione
CAS Number 1227098-15-8
Molecular Formula

C31H30O8
Molecular Weight (MW) 530.57
SMILES COC1=CC(=CC=C1O)/C=C(C(=O)\C=C\C2=CC=C(OC)C(=C2)OC)/C(=O)/C=C/C3=CC=C(OC)C(=C3)OC
InChIKey AYIYVEPNEPUJCF-GNXRPPCSSA-N

Ordering Information

Biological Activity

NF-κB-IN-1 is a potent NF-κB signaling pathway inhibitor that acts by directly inhibiting IκB kinase (IKK). By blocking IKK-mediated activation within the NF-κB signaling cascade, NF-κB-IN-1 suppresses downstream NF-κB nuclear translocation and transcriptional activity. Consequently, this pathway inhibition leads to reduced cell viability and attenuated clonogenic growth in lung cancer cells. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 50 mg/mL (94.23 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.