CAS No. 130773-02-3

Batch: Purity:99.72
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Neticonazole Hydrochloride Chemical Structure
Chemical Structure
Check the Neticonazole Hydrochloride product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 1-[(E)-2-methylsulfanyl-1-(2-pentoxyphenyl)ethenyl]imidazole;hydrochloride
CAS Number 130773-02-3
Molecular Formula

C17H22N2OS.HCl
Molecular Weight (MW) 338.9
SMILES CCCCCOC1=CC=CC=C1C(=CSC)N2C=CN=C2.Cl
InChIKey HAHMABKERDVYCH-ZUQRMPMESA-N

Ordering Information

Biological Activity

Neticonazole Hydrochloride is an imidazole antifungal agent that targets lanosterol 14α-demethylase to inhibit fungal ergosterol biosynthesis. By disrupting ergosterol synthesis, it compromises fungal cell membrane integrity and alters membrane permeability. This disruption leads to the accumulation of toxic methylated sterol intermediates and suppresses fungal cell growth and survival, demonstrating broad-spectrum activity against dermatophytes and pathogenic fungi.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 67 mg/mL (197.69 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.