CAS No. 143120-46-1

Batch: Purity:99.24
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Neotuberostemonine Chemical Structure
Chemical Structure
Check the Neotuberostemonine product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 143120-46-1
Molecular Formula

C22H33NO4
Molecular Weight (MW) 375.5
SMILES CCC1C2CCCCN3C(CC(C4C(C)C(=O)OC14)C23)C5CC(C)C(=O)O5

Ordering Information

Biological Activity

Neotuberostemonine is an antitussive alkaloid derived from Stemona tuberosa that attenuates pulmonary fibrosis by suppressing macrophage recruitment and M2 macrophage polarization. By inhibiting pro-fibrotic macrophage activation, it reduces the expression of key mediators including TGF-β1, α-SMA, and collagen to limit extracellular matrix deposition. Furthermore, neotuberostemonine suppresses hypoxia-induced differentiation of primary lung fibroblasts into myofibroblasts by modulating HIF-1α signaling. [1][2]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 75 mg/mL (199.73 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 18 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.