CAS No. 82752-99-6

Batch: Purity:99.84
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Nefazodone hydrochloride Chemical Structure
Chemical Structure
Check the Nefazodone hydrochloride product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 82752-99-6
Molecular Formula

C25H33Cl2N5O2
Molecular Weight (MW) 506.47
SMILES CCC1=NN(C(=O)N1CCOC2=CC=CC=C2)CCCN3CCN(CC3)C4=CC(=CC=C4)Cl.Cl

Biological Activity

Nefazodone hydrochloride is an atypical antidepressant that acts as a potent serotonin receptor antagonist and monoamine reuptake inhibitor. It selectively antagonizes 5-HT2A receptors while inhibiting the reuptake of serotonin and norepinephrine at the presynaptic membrane. By blocking 5-HT2A receptor signaling and altering synaptic monoamine availability, nefazodone modulates downstream serotonergic neurotransmission and neurochemical signaling pathways involved in central nervous system regulation. [1]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 25 mg/mL (49.36 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 6 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Cusack B, et al. Psychopharmacology (Berl). 1994;114(4):559-65.

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Note: Technical data last updated: Sep 1, 2026.