CAS No. 2628486-22-4
Batch:
Purity:98.12
Chemical Structure
Check the
NDI-101150
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 7-[[6-[(dimethylamino)methyl]-5-[(3S)-oxolan-3-yl]-2-pyridinyl]amino]-4-(7-fluoroimidazo[1,2-a]pyridin-3-yl)-2,3-dihydroisoindol-1-one | |
|---|---|---|
| CAS Number | 2628486-22-4 | |
| Molecular Formula |
C27H27FN6O2 |
|
| Molecular Weight (MW) | 486.54 | |
| InChIKey | QOMXZMCZISKNPU-MRXNPFEDSA-N |
Biological Activity
NDI-101150 is a potent hematopoietic progenitor kinase 1 (HPK1/MAP4K1) inhibitor. By targeting HPK1, a key negative regulator of immune cell activation, NDI-101150 selectively enhances the activity of T cells, B cells, and dendritic cells. Blockade of HPK1-mediated inhibitory signaling promotes downstream immune cell effector functions and drives robust antitumor responses, leading to significant tumor growth inhibition and complete tumor regression in syngeneic EMT-6 mouse models. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
12 mg/mL
(24.66 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 3 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.