CAS No. 2003260-55-5
Batch:
Purity:99.33
Chemical Structure
Check the
NCGC00244536
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 3-(8-hydroxyquinolin-6-yl)-N-(3-phenylpropyl)benzamide | |
|---|---|---|
| CAS Number | 2003260-55-5 | |
| Molecular Formula |
C25H22N2O2 |
|
| Molecular Weight (MW) | 382.45 | |
| SMILES | OC1=C2N=CC=CC2=CC(=C1)C3=CC(=CC=C3)C(=O)NCCCC4=CC=CC=C4 | |
| InChIKey | NYKBXXGHEMXSBB-UHFFFAOYSA-N |
NCGCis a potent KDM4 histone lysine demethylase inhibitor. By targeting KDM4 demethylases, it blocks the binding of KDM4B to the PLK1 promoter and represses the transcription of both androgen receptor (AR) and BMYB-regulated gene networks. Through these actions, NCGCselectively suppresses cancer cell growth and inhibits tumor progression in prostate cancer models. [1]
|
Concentration
Volume
Mass
|
1 mg | 5 mg | 10 mg |
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
76 mg/mL
(198.71 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 1.5 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.