CAS No. 855527-92-3
Batch:
Purity:99.07
Chemical Structure
Check the
NBI-74330
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | N-[(1R)-1-[3-(4-ethoxyphenyl)-4-oxopyrido[2,3-d]pyrimidin-2-yl]ethyl]-2-[4-fluoro-3-(trifluoromethyl)phenyl]-N-(pyridin-3-ylmethyl)acetamide | |
|---|---|---|
| CAS Number | 855527-92-3 | |
| Molecular Formula |
C32H27F4N5O3 |
|
| Molecular Weight (MW) | 605.58 | |
| InChIKey | XMRGQUDUVGRCBS-HXUWFJFHSA-N |
Biological Activity
NBI-74330 is a potent small-molecule antagonist targeting the CXC chemokine receptor 3 (CXCR3). By blocking CXCR3 receptor activation mediated by its endogenous chemokine ligands, CXCL10 and CXCL11, this compound effectively suppresses downstream CXCR3 signaling pathways, resulting in the inhibition of intracellular calcium mobilization, reduced lymphocyte chemotaxis, and diminished inflammatory cell migration responses. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(165.13 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 100 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.