CAS No. 333353-44-9
Batch:
Purity:99.86
Chemical Structure
Check the
NBD-556
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | N'-(4-chlorophenyl)-N-(2,2,6,6-tetramethylpiperidin-4-yl)oxamide | |
|---|---|---|
| CAS Number | 333353-44-9 | |
| Molecular Formula |
C17H24ClN3O2 |
|
| Molecular Weight (MW) | 337.84 | |
| SMILES | CC1(C)CC(CC(C)(C)N1)NC(=O)C(=O)NC2=CC=C(Cl)C=C2 | |
| InChIKey | ZKXLQCIOURANAD-UHFFFAOYSA-N |
NBD-556 is a low-molecular-weight human immunodeficiency virus type 1 (HIV-1) entry inhibitor that targets the envelope glycoprotein gp120 to block the gp120-CD4 interaction. By functioning as a CD4 mimetic, it induces conformational changes in gp120 that expose the coreceptor binding site. This activation promotes gp120 interaction with the CCR5 coreceptor and enhances antibody access to CD4-induced epitopes, thereby modulating downstream viral entry and infection pathways. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
68 mg/mL
(201.27 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 3 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.