CAS No. 1402837-78-8
Batch:
Purity:99.55
Chemical Structure
Check the
Navoximod
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 4-[(1R)-2-[(5S)-6-fluoro-5H-imidazo[5,1-a]isoindol-5-yl]-1-hydroxyethyl]cyclohexan-1-ol | |
|---|---|---|
| CAS Number | 1402837-78-8 | |
| Molecular Formula |
C18H21FN2O2 |
|
| Molecular Weight (MW) | 316.37 | |
| SMILES | C1CC(CCC1C(CC2C3=C(C=CC=C3F)C4=CN=CN24)O)O | |
| InChIKey | YGACXVRLDHEXKY-LHPNLFKDSA-N |
Navoximod (GDC-0919, NLG-919) is an orally bioavailable and potent inhibitor of the indoleamine 2,3-dioxygenase 1 (IDO1) pathway. By inhibiting IDO1-mediated tryptophan catabolism into immunosuppressive kynurenine, Navoximod alleviates local immune tolerance within the tumor microenvironment. This target inhibition restores effector T cell activation and proliferation, downregulates regulatory T cell suppression, and enhances overall anti-tumor immune responses. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
63 mg/mL
(199.13 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 63 mg/mL |
| Water | Insoluble |
| DMSO |
63 mg/mL
(199.13 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 63 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.