CAS No. 121679-13-8
Batch:
Purity:99.29
Chemical Structure
Check the
Naratriptan
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| CAS Number | 121679-13-8 | |
|---|---|---|
| Molecular Formula |
C17H25N3O2S |
|
| Molecular Weight (MW) | 335.47 |
Biological Activity
Naratriptan is a selective agonist of 5-hydroxytryptamine 1B and 1D (5-HT1B/1D) receptors. Activation of these G-protein-coupled receptors leads to the vasoconstriction of cranial blood vessels and inhibits the presynaptic release of pro-inflammatory neuropeptides from trigeminal nerve terminals. This dual action suppresses neurogenic inflammation and dampens nociceptive neurotransmission within the trigeminovascular pathway, ultimately reducing headache frequency.
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
67 mg/mL
(199.71 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 16 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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Note: Technical data last updated: Sep 1, 2026.