CAS No. 5144-52-5
Batch:
Purity:99.49
Chemical Structure
Check the
Naphazoline (nitrate)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 5144-52-5 | |
|---|---|---|
| Molecular Formula |
C14H14N2.HNO3 |
|
| Molecular Weight (MW) | 273.29 |
Naphazoline nitrate is an imidazoline-derived agonist targeting peripheral α2-adrenergic receptors. Engagement of α2-adrenergic receptors suppresses adenylate cyclase activity through inhibitory Gi proteins, which decreases intracellular cAMP accumulation and regulates vascular smooth muscle function. Downstream signaling induces microvascular smooth muscle constriction, thereby reducing tissue hyperemia and serving as a topical decongestant to limit localized swelling and blood flow. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
55 mg/mL
(201.25 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 6 mg/mL |
| Ethanol | 2 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.