CAS No. 3374-05-8
Batch:
Purity:99.62
Chemical Structure
Check the
Nalidixic acid sodium salt
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | sodium 1-ethyl-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylate | |
|---|---|---|
| CAS Number | 3374-05-8 | |
| Molecular Formula |
C12H12N2O3.Na |
|
| Molecular Weight (MW) | 255.23 | |
| InChIKey | ROKRAUFZFDQWLE-UHFFFAOYSA-M |
Nalidixic acid sodium salt is a synthetic quinolone antibiotic that acts as an inhibitor of bacterial DNA gyrase and topoisomerase IV. By trapping topoisomerase-cleaved DNA complexes, it disrupts essential topological alterations required during bacterial DNA replication and transcription. This leads to double-stranded DNA breaks, activation of the bacterial SOS repair pathway, and swift cessation of DNA synthesis, culminating in bactericidal activity against susceptible bacterial strains.[1][2]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| Water | 51 mg/mL |
| Ethanol | 3 mg/mL |
| DMSO |
Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.