CAS No. 31750-48-8

Batch: Purity:98.95
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N-Desmethyltamoxifen Chemical Structure
Chemical Structure
Check the N-Desmethyltamoxifen product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 2-[4-[(Z)-1,2-diphenylbut-1-enyl]phenoxy]-N-methylethanamine
CAS Number 31750-48-8
Molecular Formula

C25H27NO
Molecular Weight (MW) 357.49
SMILES CC/C(C1=CC=CC=C1)=C(C2=CC=CC=C2)/C3=CC=C(OCCNC)C=C3
InChIKey NYDCDZSEEAUOHN-IZHYLOQSSA-N

Biological Activity

N-Desmethyltamoxifen is a triphenylethylene metabolite and protein kinase C (PKC) inhibitor. In acute myelogenous leukemia cells, it regulates sphingolipid pathways by inhibiting ceramide glycosylation and acid ceramidase-mediated ceramide hydrolysis, while reducing sphingosine and sphingosine-1-phosphate production. These metabolic alterations block ceramide clearance and elevate pro-apoptotic ceramide levels, resulting in enhanced apoptotic cell death. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 72 mg/mL (201.4 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 36 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] O'Brian CA, et al. J Natl Cancer Inst. 1986;76(6):1243-6.

[2] Morad SA, et al. Biochim Biophys Acta. 2015;1851(7):919-28.

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Note: Technical data last updated: Sep 1, 2026.