CAS No. 1242137-16-1

Batch: Purity:99.96
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N-desMethyl EnzalutaMide Chemical Structure
Chemical Structure
Check the N-desMethyl EnzalutaMide product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 4-[3-[4-cyano-3-(trifluoromethyl)phenyl]-5,5-dimethyl-4-oxo-2-sulfanylideneimidazolidin-1-yl]-2-fluorobenzamide
CAS Number 1242137-16-1
Molecular Formula

C20H14F4N4O2S
Molecular Weight (MW) 450.41
SMILES CC1(C)N(C(=S)N(C1=O)C2=CC(=C(C=C2)C#N)C(F)(F)F)C3=CC(=C(C=C3)C(N)=O)F
InChIKey JSFOGZGIBIQRPU-UHFFFAOYSA-N

Ordering Information

Biological Activity

N-desMethyl Enzalutamide is a potent androgen receptor inhibitor and the primary active metabolite of enzalutamide. It targets the androgen receptor signaling pathway by inhibiting androgen binding, preventing nuclear translocation of the receptor, and impairing chromosomal DNA binding. This inhibition suppresses downstream androgen receptor-mediated gene transcription, leading to reduced cellular proliferation and induction of apoptosis in castration-resistant prostate cancer cells.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 90 mg/mL (199.81 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 5 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.