CAS No. 132201-33-3

Batch: Purity:99.94
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N-Benzoyl-(2R,3S)-3-phenylisoserine Chemical Structure
Chemical Structure
Check the N-Benzoyl-(2R,3S)-3-phenylisoserine product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 132201-33-3
Molecular Formula

C16H15NO4
Molecular Weight (MW) 285.29
SMILES C1=CC=C(C=C1)C(C(C(=O)O)O)NC(=O)C2=CC=CC=C2

Ordering Information

Biological Activity

N-Benzoyl-(2R,3S)-3-phenylisoserine is an essential structural component and side chain moiety of paclitaxel that plays a critical role in microtubule-stabilizing and antitumor activities. As part of the paclitaxel structure, this component promotes tubulin polymerization and stabilizes microtubule polymers, disrupting normal mitotic spindle dynamics. Consequently, it induces cell cycle arrest at the G2/M phase and triggers apoptosis in cancer cells.

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 57 mg/mL (199.79 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.