CAS No. 68573-24-0

Batch: Purity:99.99
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N-(p-Coumaroyl) Serotonin Chemical Structure
Chemical Structure
Check the N-(p-Coumaroyl) Serotonin product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-3-(4-hydroxyphenyl)prop-2-enamide
CAS Number 68573-24-0
Molecular Formula

C19H18N2O3
Molecular Weight (MW) 322.36
SMILES NA
InChIKey WLZPAFGVOWCVMG-UHFFFAOYSA-N

Ordering Information

Biological Activity

N-(p-Coumaroyl) Serotonin is a natural polyphenol isolated from safflower seeds that acts as an inhibitor of platelet-derived growth factor (PDGF) signaling. It attenuates PDGF-induced phosphorylation of the PDGF receptor and downstream ERK1/2 signaling while blocking sarcoplasmic reticulum Ca2+ release. Through these anti-atherogenic, antioxidative, and anti-inflammatory mechanisms, it suppresses vascular smooth muscle cell proliferation and migration and improves aortic wall distensibility.[1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 64 mg/mL (198.53 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 64 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.