CAS No. 2839908-40-4
Batch:
Purity:96.72
Chemical Structure
Check the
MZ-101
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | (2S,4R)-4-fluoro-N-[(S)-phenyl-(4-propan-2-ylphenyl)methyl]-1-[2-(2H-triazol-4-yl)acetyl]pyrrolidine-2-carboxamide | |
|---|---|---|
| CAS Number | 2839908-40-4 | |
| Molecular Formula |
C25H28FN5O2 |
|
| Molecular Weight (MW) | 449.52 | |
| InChIKey | VIXMWFGMNPKXHI-SFLYRZDNSA-N |
Biological Activity
MZ-101 is a small-molecule inhibitor of glycogen synthase 1 (GYS1) with an ICof. By inhibiting muscle glycogen synthesis, MZ-101 depletes glycogen stores and prevents pathological glycogen accumulation. Downstream, MZ-101 treatment normalizes tissue glycogen levels and corrects transcriptional and metabolic abnormalities in Pompe mouse models, restoring cellular homeostasis without affecting liver glycogen synthesis. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
90 mg/mL
(200.21 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 90 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.