CAS No. 171485-39-5
Batch:
Purity:98.94
Chemical Structure
Check the
Myrislignan
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 4-[(1R,2S)-2-(2,6-dimethoxy-4-prop-2-enylphenoxy)-1-hydroxypropyl]-2-methoxyphenol | |
|---|---|---|
| CAS Number | 171485-39-5 | |
| Molecular Formula |
C21H26O6 |
|
| Molecular Weight (MW) | 374.43 | |
| InChIKey | ULZFTGWWPHYLGI-RBZFPXEDSA-N |
Myrislignan is a natural lignan isolated from Myristica fragrans Houtt that exhibits anti-inflammatory activity through inhibition of the NF-κB signaling pathway. Downstream of NF-κB pathway suppression, myrislignan dose-dependently reduces the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in lipopolysaccharide (LPS)-stimulated macrophage cells. Consequently, it inhibits the production and release of inflammatory cytokines, including interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α). [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(267.07 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.